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Issue 22, 2018

Narrowing the diversification of supramolecular assemblies by preorganization

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Abstract

We designed and synthesized three phosphorylated peptides as precursors of the same peptide Nap-YYY. We found that different precursors led to different materials with almost identical chemical compositions at the final stages. Only Nap-YpYY could form very uniform nanofibers in a stable supramolecular hydrogel by enzyme-instructed self-assembly (EISA) at the physiological temperature (37 °C). In contrast, de-phosphorylation of the other two precursors (Nap-pYYY and Nap-YYpY) resulted in diverse nanostructures in metastable hydrogels with precipitates. The formation of uniform nanomaterials in the stable hydrogels was due to the preorganization property of the precursor Nap-YpYY, which facilitated rapid folding and accelerated the kinetics of hydrogelation of the resulting peptide Nap-YYY generated by the EISA process. Our study demonstrated the importance of the precursor for the self-assembly of nanomaterials and provided a useful strategy to manipulate them.

Graphical abstract: Narrowing the diversification of supramolecular assemblies by preorganization

Supplementary files

Article information


Submitted
07 Feb 2018
Accepted
19 Feb 2018
First published
19 Feb 2018

Chem. Commun., 2018,54, 2751-2754
Article type
Communication

Narrowing the diversification of supramolecular assemblies by preorganization

Z. Wang, C. Liang, Y. Shang, S. He, L. Wang and Z. Yang, Chem. Commun., 2018, 54, 2751 DOI: 10.1039/C8CC01082J

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