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Issue 26, 2018
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Combining cooperativity with sequestration: a novel strategy for discrimination of single nucleotide variants

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Abstract

We present a novel strategy for the discrimination of single nucleotide variants (SNVs) by combining cooperativity with sequestration, which displays remarkably high specificity (discrimination factors ranging from 67 to 618 with a median of 194) against 12 model SNVs and can be easily integrated with PCR amplification to detect KRAS G12D mutation.

Graphical abstract: Combining cooperativity with sequestration: a novel strategy for discrimination of single nucleotide variants

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Supplementary files

Article information


Submitted
31 Jan 2018
Accepted
02 Mar 2018
First published
02 Mar 2018

Chem. Commun., 2018,54, 3223-3226
Article type
Communication

Combining cooperativity with sequestration: a novel strategy for discrimination of single nucleotide variants

S. Hu, N. Li and F. Liu, Chem. Commun., 2018, 54, 3223
DOI: 10.1039/C8CC00838H

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