A headgroup linker perturbs pKavia acyl chain migration: designing base-labile supramolecular assemblies

Avijit Sardar; Nilesh K. Rout; Soumav Nath; Mahesh Prasad; Jnansankar Mahanti; Santanu Mondal; Pradip K. Tarafdar

doi:10.1039/C8CC00776D

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A headgroup linker perturbs pK_avia acyl chain migration: designing base-labile supramolecular assemblies†

Avijit Sardar,^a Nilesh K. Rout,^a Soumav Nath,^a Mahesh Prasad,^a Jnansankar Mahanti,^a Santanu Mondal^a and Pradip K. Tarafdar

*^a

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* Corresponding authors

^a Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal, India
E-mail: srpradip@gmail.com

Abstract

Acyl chain transfer, which perturbs the protonation equilibrium of amine and reduces the apparent pK_a by 2.0–2.5 units, is used to develop a liposome-based drug delivery system.

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Article information

DOI: https://doi.org/10.1039/C8CC00776D
Article type: Communication
Submitted: 29 Jan 2018
Accepted: 28 Mar 2018
First published: 29 Mar 2018

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Chem. Commun., 2018,54, 4282-4285

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A headgroup linker perturbs pK_avia acyl chain migration: designing base-labile supramolecular assemblies

A. Sardar, N. K. Rout, S. Nath, M. Prasad, J. Mahanti, S. Mondal and P. K. Tarafdar, Chem. Commun., 2018, 54, 4282 DOI: 10.1039/C8CC00776D

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