Jump to main content
Jump to site search

Issue 45, 2018
Previous Article Next Article

Pressure and cosolvent modulation of the catalytic activity of amyloid fibrils

Author affiliations

Abstract

We report on the effects of pressure and cosolvents on the catalytic activity of a designed amyloid fibril by applying a high-pressure stopped-flow methodology with rapid spectroscopic detection. FTIR spectroscopic data revealed a remarkable pressure and temperature stability of the fibrillar catalyst. The activity is further enhanced by osmolytes and macromolecular crowding.

Graphical abstract: Pressure and cosolvent modulation of the catalytic activity of amyloid fibrils

Back to tab navigation

Supplementary files

Article information


Submitted
26 Jan 2018
Accepted
17 Apr 2018
First published
17 Apr 2018

Chem. Commun., 2018,54, 5696-5699
Article type
Communication

Pressure and cosolvent modulation of the catalytic activity of amyloid fibrils

M. W. Jaworek, V. Schuabb and R. Winter, Chem. Commun., 2018, 54, 5696
DOI: 10.1039/C8CC00699G

Social activity

Search articles by author

Spotlight

Advertisements