Issue 24, 2018

Modulating the rigidity of nanoparticles for tumor penetration

Abstract

How the rigidity of nanoparticles affects their penetration into tumors is unclear. Core–shell nanoparticles were prepared with amphipathic poly(ethylene glycol)-b-(poly ε-caprolactone-g-poly butyl acrylate) (PEG–(PCL-g-PBA)) so that the mechanical stiffness of their cores could be varied in order to test the relationship between their rigidity and penetration through tumors. The rigidity of the nanoparticles was adjusted by the changeable crystallinity of the core, which was altered by varying the ratio of ε-caprolactone and butyl acrylate.

Graphical abstract: Modulating the rigidity of nanoparticles for tumor penetration

Supplementary files

Article information

Article type
Communication
Submitted
17 Jan 2018
Accepted
22 Feb 2018
First published
23 Feb 2018

Chem. Commun., 2018,54, 3014-3017

Modulating the rigidity of nanoparticles for tumor penetration

H. Deng, K. Song, J. Zhang, L. Deng, A. Dong and Z. Qin, Chem. Commun., 2018, 54, 3014 DOI: 10.1039/C8CC00398J

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