Issue 57, 2018

Staudinger reaction using 2,6-dichlorophenyl azide derivatives for robust aza-ylide formation applicable to bioconjugation in living cells

Abstract

Efficient formation of water- and air-stable aza-ylides has been achieved using the Staudinger reaction between electron-deficient aromatic azides such as 2,6-dichlorophenyl azide and triarylphosphines. The reaction proceeds rapidly and has been successfully applied to chemical modification of proteins in living cells.

Graphical abstract: Staudinger reaction using 2,6-dichlorophenyl azide derivatives for robust aza-ylide formation applicable to bioconjugation in living cells

Supplementary files

Article information

Article type
Communication
Submitted
09 Jan 2018
Accepted
13 May 2018
First published
14 May 2018
This article is Open Access
Creative Commons BY license

Chem. Commun., 2018,54, 7904-7907

Staudinger reaction using 2,6-dichlorophenyl azide derivatives for robust aza-ylide formation applicable to bioconjugation in living cells

T. Meguro, N. Terashima, H. Ito, Y. Koike, I. Kii, S. Yoshida and T. Hosoya, Chem. Commun., 2018, 54, 7904 DOI: 10.1039/C8CC00179K

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