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Issue 51, 2018
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Carboxylic and O-acetyl moieties are essential for the immunostimulatory activity of glucuronoxylomannan: a novel TLR4 specific immunostimulator from Auricularia auricula-judae

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Abstract

This study established the comprehensive repeating unit structure of immunologically active glucuronoxylomannan (AAPS) from wood ear mushroom, Auricularia auricula-judae. We identified Toll-like receptor 4 (TLR4) as a critical receptor involved in AAPS-induced macrophage activation to secrete pro-inflammatory cytokines. Molecular modeling data and chemical modifications of AAPS revealed that both carboxylic and acetyl moieties of AAPS are equally essential in TLR4 binding to exert in vitro immunostimulatory activity.

Graphical abstract: Carboxylic and O-acetyl moieties are essential for the immunostimulatory activity of glucuronoxylomannan: a novel TLR4 specific immunostimulator from Auricularia auricula-judae

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Supplementary files

Article information


Submitted
29 Dec 2017
Accepted
16 May 2018
First published
18 May 2018

Chem. Commun., 2018,54, 6995-6998
Article type
Communication

Carboxylic and O-acetyl moieties are essential for the immunostimulatory activity of glucuronoxylomannan: a novel TLR4 specific immunostimulator from Auricularia auricula-judae

N. Perera, F. Yang, J. Chern, H. Chiu, C. Hsieh, L. Li, Y. Zhang, K. Hua and S. Wu, Chem. Commun., 2018, 54, 6995 DOI: 10.1039/C7CC09927D

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