In vivo drug tracking with 19F MRI at therapeutic dose

Shaowei Bo; Yaping Yuan; Yongping Chen; Zhigang Yang; Shizhen Chen; Xin Zhou; Zhong-Xing Jiang

doi:10.1039/C7CC09898G

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In vivo drug tracking with ¹⁹F MRI at therapeutic dose†

Shaowei Bo,^a Yaping Yuan,^b Yongping Chen,^a Zhigang Yang,^b Shizhen Chen,^b Xin Zhou^b and Zhong-Xing Jiang

*^a

Author affiliations

* Corresponding authors

^a Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
E-mail: zxjiang@whu.edu.cn

^b State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China

Abstract

Tracking drugs with ¹⁹F MRI would be beneficial for developing theranostics and optimizing drug therapy. To this end, a fluorinated dendritic amphiphile with high ¹⁹F MRI sensitivity and biocompatibility has been developed for ¹⁹F MRI tracking of doxorubicin (DOX)-loaded liposomes in mice, which may provide an effective platform to in vivo trace various drugs with ¹⁹F MRI.

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Article information

DOI: https://doi.org/10.1039/C7CC09898G
Article type: Communication
Submitted: 27 Dec 2017
Accepted: 21 Mar 2018
First published: 21 Mar 2018

Download Citation

Chem. Commun., 2018,54, 3875-3878

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In vivo drug tracking with ¹⁹F MRI at therapeutic dose

S. Bo, Y. Yuan, Y. Chen, Z. Yang, S. Chen, X. Zhou and Z. Jiang, Chem. Commun., 2018, 54, 3875 DOI: 10.1039/C7CC09898G

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Chemical Communications