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Issue 14, 2018

An allylated firefly luciferin analogue with luciferase specific response in living cells

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Abstract

An allylated firefly luciferin was successfully synthesized and its bioluminescence properties were evaluated. When applied to cellular imaging in combination with Eluc, which is one of the commercially available luciferases, this analogue displayed a luciferase-specific bioluminescence signal with prolonged emission (>100 min).

Graphical abstract: An allylated firefly luciferin analogue with luciferase specific response in living cells

Supplementary files

Article information


Submitted
20 Dec 2017
Accepted
19 Jan 2018
First published
24 Jan 2018

Chem. Commun., 2018,54, 1774-1777
Article type
Communication

An allylated firefly luciferin analogue with luciferase specific response in living cells

Y. Ikeda, T. Saitoh, K. Niwa, T. Nakajima, N. Kitada, S. A. Maki, M. Sato, D. Citterio, S. Nishiyama and K. Suzuki, Chem. Commun., 2018, 54, 1774 DOI: 10.1039/C7CC09720D

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