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Issue 24, 2018
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Accessing highly functionalized cyclopentanoids via a cascade palladation approach: unprecedented benzylic C–H activation towards cyclopentenoindanes

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Abstract

A Pd-catalyzed synthesis of 3,4,5-trisubstituted cyclopentenes from diazabicyclic olefins and o-iodobenzoates has been developed. The hitherto unknown cascade process involves three stages: carbopalladation, oxypalladation and a Tsuji–Trost reaction. We have also developed a facile route involving a novel benzylic C–H activation towards cyclopentenoindane moieties.

Graphical abstract: Accessing highly functionalized cyclopentanoids via a cascade palladation approach: unprecedented benzylic C–H activation towards cyclopentenoindanes

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Article information


Submitted
12 Dec 2017
Accepted
23 Feb 2018
First published
23 Feb 2018

Chem. Commun., 2018,54, 2982-2985
Article type
Communication

Accessing highly functionalized cyclopentanoids via a cascade palladation approach: unprecedented benzylic C–H activation towards cyclopentenoindanes

P. V. Santhini, A. S. Smrithy, C. P. Irfana Jesin, S. Varughese, J. John and K. V. Radhakrishnan, Chem. Commun., 2018, 54, 2982
DOI: 10.1039/C7CC09521J

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