A copper-catalyzed reaction of 3-diazoindolin-2-imines with 2-(phenylamino)ethanols: convenient access to spiro[indoline-3,2′-oxazolidin]-2-imines

Abstract

3-Diazoindolin-2-imines reacted with chiral 2-(phenylamino)ethanols under copper catalysis to furnish chiral spiro[indoline-3,2′-oxazolidin]-2-imines in good yields with excellent diastereoselectivity. The reaction undergoes a copper-catalyzed cascade process involving the formation of copper carbene, C–N coupling, and C–O coupling.