Modular tripodal receptors for the hydrosulfide (HS−) anion

Abstract

Hydrogen sulfide (H₂S) is an endogenously-produced gasotransmitter and is predominantly speciated as HS⁻ at physiological pH. Despite this importance, reversible binding of HS⁻ to synthetic receptors remains rare and confined to highly-engineered receptor systems. Here we demonstrate the generality of reversible HS⁻ binding in a family of tren-based receptors.