Issue 20, 2018

Identification of a rhodium(iii) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells

Abstract

The rhodium(III) complex 1 was identified as a potent Wee1 inhibitor in vitro and in cellulo. It decreased Wee1 activity and unscheduled mitotic entry, and induced cell damage and death in TP53-mutated triple-negative breast cancer cells. 1 represents a promising scaffold for further development of more potent metal-based Wee1 antagonists.

Graphical abstract: Identification of a rhodium(iii) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells

Supplementary files

Article information

Article type
Communication
Submitted
07 Dec 2017
Accepted
16 Jan 2018
First published
16 Jan 2018

Chem. Commun., 2018,54, 2463-2466

Identification of a rhodium(III) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells

G. Yang, H. Zhong, C. Ko, S. Wong, K. Vellaisamy, M. Ye, D. Ma and C. Leung, Chem. Commun., 2018, 54, 2463 DOI: 10.1039/C7CC09384E

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