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Issue 15, 2018
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N terminal N-methylation modulates chiral centre induced helical (CIH) peptides’ biophysical properties

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Abstract

The effects of N-methylation on CIH peptides’ biophysical properties were systematically studied. N-Methylation at the N terminal NH could help improve the peptides’ cellular uptake with a retained helical conformation. This N-methylation strategy could also be applied to longer peptides to improve their stability and cellular uptake.

Graphical abstract: N terminal N-methylation modulates chiral centre induced helical (CIH) peptides’ biophysical properties

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Publication details

The article was received on 30 Nov 2017, accepted on 23 Jan 2018 and first published on 23 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC09201F
Citation: Chem. Commun., 2018,54, 1865-1868

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    N terminal N-methylation modulates chiral centre induced helical (CIH) peptides’ biophysical properties

    W. Li, K. Hu, Q. Zhang, D. Wang, Y. Ma, Z. Hou, F. Yin and Z. Li, Chem. Commun., 2018, 54, 1865
    DOI: 10.1039/C7CC09201F

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