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Issue 32, 2018
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A phage display-based strategy for the de novo creation of disulfide-constrained and isomer-free bicyclic peptide affinity reagents

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Abstract

Bicyclic peptides have been attractive scaffolds for developing high affinity reagents for biomacromolecules. Here we report a general phage-screening strategy for the development of bicyclic peptide ligands constrained with isomerically-forbidden disulfide bridges without elaborate chemical modifications and recourses to genetic code reprogramming.

Graphical abstract: A phage display-based strategy for the de novo creation of disulfide-constrained and isomer-free bicyclic peptide affinity reagents

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Publication details

The article was received on 28 Nov 2017, accepted on 26 Mar 2018 and first published on 26 Mar 2018


Article type: Communication
DOI: 10.1039/C7CC09142G
Citation: Chem. Commun., 2018,54, 4029-4032

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    A phage display-based strategy for the de novo creation of disulfide-constrained and isomer-free bicyclic peptide affinity reagents

    M. Zha, P. Lin, H. Yao, Y. Zhao and C. Wu, Chem. Commun., 2018, 54, 4029
    DOI: 10.1039/C7CC09142G

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