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Issue 10, 2018
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Expanding the chemical diversity of TNA with tUTP derivatives that are substrates for a TNA polymerase

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Abstract

Expanding the chemical diversity of threose nucleic acid (TNA) beyond the natural bases would enable the development of TNA polymers with enhanced physicochemical properties. Here, we describe a versatile approach for increasing the chemical diversity of TNA using 5-alkynyl-modified α-L-threofuranosyl uridine triphosphates that are substrates for a TNA polymerase.

Graphical abstract: Expanding the chemical diversity of TNA with tUTP derivatives that are substrates for a TNA polymerase

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Article information


Submitted
27 Nov 2017
Accepted
10 Jan 2018
First published
17 Jan 2018

Chem. Commun., 2018,54, 1237-1240
Article type
Communication

Expanding the chemical diversity of TNA with tUTP derivatives that are substrates for a TNA polymerase

H. Mei and J. C. Chaput, Chem. Commun., 2018, 54, 1237
DOI: 10.1039/C7CC09130C

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