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Issue 3, 2018
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Responsive DNA G-quadruplex micelles

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Abstract

A novel and versatile design of DNA–lipid conjugates is presented. The assembly of the DNA headgroups into G-quadruplex structures is essential for the formation of micelles and their stability. By hybridization with a complementary oligonucleotide the micelles were destabilized, resulting in cargo release. In combination with a hairpin DNA aptamer as complementary strand, the release is obtained selectively by the presence of ATP.

Graphical abstract: Responsive DNA G-quadruplex micelles

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Article information


Submitted
16 Oct 2017
Accepted
06 Dec 2017
First published
06 Dec 2017

Chem. Commun., 2018,54, 260-263
Article type
Communication

Responsive DNA G-quadruplex micelles

L. Cozzoli, L. Gjonaj, M. C. A. Stuart, B. Poolman and G. Roelfes, Chem. Commun., 2018, 54, 260
DOI: 10.1039/C7CC07899D

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