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Issue 97, 2017
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Phosphine catalysed (5 + 1) annulation of ynone/cinnamates with primary amines

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Abstract

The (5 + 1) annulation of ynone/cinnamates and related substrates with protected primary amines gives rise to isoquinolones, pyrrolidinones and pyrrolopiperazines in good to excellent yields under phosphine catalysis. The reaction is viable with chiral phosphines, although the selectivity is poor.

Graphical abstract: Phosphine catalysed (5 + 1) annulation of ynone/cinnamates with primary amines

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Article information


Submitted
26 Oct 2017
Accepted
10 Nov 2017
First published
10 Nov 2017

Chem. Commun., 2017,53, 13071-13074
Article type
Communication

Phosphine catalysed (5 + 1) annulation of ynone/cinnamates with primary amines

J. Ametovski, U. Dutta, L. Burchill, D. Maiti, D. W. Lupton and J. F. Hooper, Chem. Commun., 2017, 53, 13071
DOI: 10.1039/C7CC08252E

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