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Issue 97, 2017
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Use of azidonaphthalimide carboxylic acids as fluorescent templates with a built-in photoreactive group and a flexible linker simplifies protein labeling studies: applications in selective tagging of HCAII and penicillin binding proteins

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Abstract

This work describes the synthesis of azidonaphthalimide carboxylic acids which act as fluorescent templates with a built-in photoreactive group and a linker thus simplifying the design of protein labeling agents. These were separately connected to selectivity hands like a sulfonamide and ampicillin for successful labeling/detection of HCAII and PBPs, respectively.

Graphical abstract: Use of azidonaphthalimide carboxylic acids as fluorescent templates with a built-in photoreactive group and a flexible linker simplifies protein labeling studies: applications in selective tagging of HCAII and penicillin binding proteins

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Submitted
24 Oct 2017
Accepted
06 Nov 2017
First published
06 Nov 2017

Chem. Commun., 2017,53, 13015-13018
Article type
Communication

Use of azidonaphthalimide carboxylic acids as fluorescent templates with a built-in photoreactive group and a flexible linker simplifies protein labeling studies: applications in selective tagging of HCAII and penicillin binding proteins

M. Singha, S. Roy, S. D. Pandey, S. S. Bag, P. Bhattacharya, M. Das, A. S. Ghosh, D. Ray and A. Basak, Chem. Commun., 2017, 53, 13015
DOI: 10.1039/C7CC08209F

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