Jump to main content
Jump to site search

Issue 96, 2017
Previous Article Next Article

Asymmetric formal synthesis of (+)-cycloclavine

Author affiliations


The asymmetric synthesis of Szántay's amine (+)-2, the pivotal precursor for direct access to (+)-cycloclavine (1), is described for the first time in eleven steps with 19.7% overall yield from the commercially available 4-bromoindole. The strategy features an asymmetric induction by Ellman's sulfinimine and rhodium-catalysed isomerization of the C[double bond, length as m-dash]C bond.

Graphical abstract: Asymmetric formal synthesis of (+)-cycloclavine

Back to tab navigation

Supplementary files

Article information

18 Oct 2017
30 Oct 2017
First published
30 Oct 2017

Chem. Commun., 2017,53, 12902-12905
Article type

Asymmetric formal synthesis of (+)-cycloclavine

J. Chen, L. Song, F. Li, Z. Shi and X. Cao, Chem. Commun., 2017, 53, 12902
DOI: 10.1039/C7CC08044A

Social activity

Search articles by author