Issue 97, 2017

Ruthenium catalyzed remote C4-selective C–H functionalisation of carbazoles via σ-activation

Abstract

We report the C4-selective C–H alkylation of carbazole derivatives furnished with a pyrimidine directing group at N9. This was realized using ruthenium catalyzed σ-activation methodology, whereby C–H activation at C1 enables the interaction of this ruthenacycle, at the para position to the metal center, with tertiary alkyl radicals.

Graphical abstract: Ruthenium catalyzed remote C4-selective C–H functionalisation of carbazoles via σ-activation

Supplementary files

Article information

Article type
Communication
Submitted
29 Sep 2017
Accepted
15 Nov 2017
First published
16 Nov 2017
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 13039-13042

Ruthenium catalyzed remote C4-selective C–H functionalisation of carbazoles via σ-activation

J. A. Leitch, C. J. Heron, J. McKnight, G. Kociok-Köhn, Y. Bhonoah and C. G. Frost, Chem. Commun., 2017, 53, 13039 DOI: 10.1039/C7CC07606A

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