Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 95, 2017
Previous Article Next Article

Synthesis and characterization of the first inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD)

Author affiliations

Abstract

N-Acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is a membrane-associated zinc enzyme that catalyzes the hydrolysis of N-acylphosphatidylethanolamines (NAPEs) into fatty acid ethanolamides (FAEs). Here, we describe the identification of the first small-molecule NAPE-PLD inhibitor, the quinazoline sulfonamide derivative 2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide, ARN19874.

Graphical abstract: Synthesis and characterization of the first inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD)

Back to tab navigation

Supplementary files

Publication details

The article was received on 30 Sep 2017, accepted on 06 Nov 2017 and first published on 16 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC07582K
Citation: Chem. Commun., 2017,53, 12814-12817

  •   Request permissions

    Synthesis and characterization of the first inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD)

    B. Castellani, E. Diamanti, D. Pizzirani, P. Tardia, M. Maccesi, N. Realini, P. Magotti, G. Garau, T. Bakkum, S. Rivara, M. Mor and D. Piomelli, Chem. Commun., 2017, 53, 12814
    DOI: 10.1039/C7CC07582K

Search articles by author

Spotlight

Advertisements