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Issue 93, 2017
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Ni-Catalyzed cross-coupling reactions of N-acylpyrrole-type amides with organoboron reagents

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Abstract

The catalytic conversion of amides to ketones is highly desirable yet challenging in organic synthesis. We herein report the first Ni/bis-NHC-catalyzed cross-coupling of N-acylpyrrole-type amides with arylboronic esters to obtain diarylketones. This method is facilitated by a new chelating bis-NHC ligand. The reaction tolerates diverse functional groups on both arylamide and arylboronic ester partners including sensitive ester and ketone groups.

Graphical abstract: Ni-Catalyzed cross-coupling reactions of N-acylpyrrole-type amides with organoboron reagents

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Supplementary files

Article information


Submitted
25 Sep 2017
Accepted
02 Nov 2017
First published
02 Nov 2017

Chem. Commun., 2017,53, 12584-12587
Article type
Communication

Ni-Catalyzed cross-coupling reactions of N-acylpyrrole-type amides with organoboron reagents

P. Huang and H. Chen, Chem. Commun., 2017, 53, 12584 DOI: 10.1039/C7CC07457C

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