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Issue 91, 2017
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Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography

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Abstract

By using the Inverted Chirality Columns Approach (ICCA) we have developed an enantioselective UHPSFC method to determine the enantiomeric excess (ee) of (−)-Δ9-THC in medicinal marijuana (Bedrocan®). The ee was high (99.73%), but the concentration of the (+)-enantiomer (0.135%) was not negligible, and it is worth a systematic evaluation of bioactivity.

Graphical abstract: Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography

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Publication details

The article was received on 06 Sep 2017, accepted on 17 Oct 2017 and first published on 17 Oct 2017


Article type: Communication
DOI: 10.1039/C7CC06999E
Citation: Chem. Commun., 2017,53, 12262-12265
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    Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography

    G. Mazzoccanti, O. H. Ismail, I. D’Acquarica, C. Villani, C. Manzo, M. Wilcox, A. Cavazzini and F. Gasparrini, Chem. Commun., 2017, 53, 12262
    DOI: 10.1039/C7CC06999E

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