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Issue 91, 2017
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Taming photo-induced oxidation degradation of dihydropyridine drugs through cocrystallization

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Abstract

Cocrystallization of nifedipine (NFD) and isonicotinamide (INA) resulted in two monotropic cocrystal polymorphs. The thermodynamically more stable polymorph presents superior photostability compared to the other. Cocrystallization can be an efficient approach to address the stability deficit of dihydropyridine drugs.

Graphical abstract: Taming photo-induced oxidation degradation of dihydropyridine drugs through cocrystallization

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Article information


Submitted
06 Sep 2017
Accepted
16 Oct 2017
First published
16 Oct 2017

Chem. Commun., 2017,53, 12266-12269
Article type
Communication

Taming photo-induced oxidation degradation of dihydropyridine drugs through cocrystallization

Q. Yu, Z. Yan, J. Bao, J. Wang and X. Mei, Chem. Commun., 2017, 53, 12266
DOI: 10.1039/C7CC06992H

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