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Issue 75, 2017
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A modular design for minor groove binding and recognition of mixed base pair sequences of DNA

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Abstract

The design and synthesis of compounds that target mixed, AT/GC, DNA sequences is described. The design concept connects two N-methyl-benzimidazole-thiophene single GC recognition units with a flexible linker that lets the compound fit the shape and twist of the DNA minor groove while covering a full turn of the double helix.

Graphical abstract: A modular design for minor groove binding and recognition of mixed base pair sequences of DNA

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Supplementary files

Article information


Submitted
09 Aug 2017
Accepted
01 Sep 2017
First published
01 Sep 2017

Chem. Commun., 2017,53, 10406-10409
Article type
Communication

A modular design for minor groove binding and recognition of mixed base pair sequences of DNA

P. Guo, A. Paul, A. Kumar, N. K. Harika, S. Wang, A. A. Farahat, D. W. Boykin and W. D. Wilson, Chem. Commun., 2017, 53, 10406
DOI: 10.1039/C7CC06246J

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