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Issue 74, 2017
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Visible light photocatalytic decarboxylative monofluoroalkenylation of α-amino acids with gem-difluoroalkenes

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Abstract

α-Amino acids are among the most common biologically active molecules in nature, and their functionalization has attracted much attention. In this communication, a novel, efficient and general visible-light photocatalytic decarboxylative monofluoroalkenylation of N-protected α-amino acids with gem-difluoroalkenes is reported, affording the corresponding α-amino monofluoroalkenes which might find applications in medical chemistry and materials science. The reaction proceeded at room temperature with high efficiency and tolerance of various functional groups.

Graphical abstract: Visible light photocatalytic decarboxylative monofluoroalkenylation of α-amino acids with gem-difluoroalkenes

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Supplementary files

Article information


Submitted
25 Jul 2017
Accepted
29 Aug 2017
First published
29 Aug 2017

Chem. Commun., 2017,53, 10299-10302
Article type
Communication

Visible light photocatalytic decarboxylative monofluoroalkenylation of α-amino acids with gem-difluoroalkenes

J. Li, Q. Lefebvre, H. Yang, Y. Zhao and H. Fu, Chem. Commun., 2017, 53, 10299
DOI: 10.1039/C7CC05758J

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