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Issue 75, 2017
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Ruthenium catalyzed β-C(sp3)–H functionalization on the ‘privileged’ piperazine nucleus

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Abstract

β-C(sp3)–H functionalization on the ‘privileged’ piperazine nucleus has been disclosed using ruthenium catalysis. The ruthenium catalyzed synthesis of a variety of piperazine fused indoles from ortho-piperazinyl (hetero)aryl aldehydes is presented. This transformation takes place via the dehydrogenation of piperazine followed by an intramolecular nucleophilic addition of the transient enamine moiety onto the carbonyl group and aromatization cascade.

Graphical abstract: Ruthenium catalyzed β-C(sp3)–H functionalization on the ‘privileged’ piperazine nucleus

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Article information


Submitted
19 Jul 2017
Accepted
30 Aug 2017
First published
30 Aug 2017

Chem. Commun., 2017,53, 10448-10451
Article type
Communication

Ruthenium catalyzed β-C(sp3)–H functionalization on the ‘privileged’ piperazine nucleus

V. Murugesh, C. Bruneau, M. Achard, A. R. Sahoo, G. V. M. Sharma and S. Suresh, Chem. Commun., 2017, 53, 10448
DOI: 10.1039/C7CC05604D

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