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Issue 91, 2017
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Programming membrane permeability using integrated membrane pores and blockers as molecular regulators

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Abstract

We report a bottom-up synthetic biology approach to engineering vesicles with programmable permeabilities. Exploiting the concentration-dependent relationship between constitutively active pores (alpha-hemolysin) and blockers allows blockers to behave as molecular regulators for tuning permeability, enabling us to systematically modulate cargo release kinetics without changing the lipid fabric of the system.

Graphical abstract: Programming membrane permeability using integrated membrane pores and blockers as molecular regulators

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Publication details

The article was received on 13 Jul 2017, accepted on 16 Oct 2017 and first published on 01 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC05423H
Citation: Chem. Commun., 2017,53, 12282-12285
  • Open access: Creative Commons BY license
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    Programming membrane permeability using integrated membrane pores and blockers as molecular regulators

    J. M. Thomas, M. S. Friddin, O. Ces and Y. Elani, Chem. Commun., 2017, 53, 12282
    DOI: 10.1039/C7CC05423H

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