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Issue 60, 2017
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Synthesis and incorporation of an advanced lipid peroxidation end-product building block into collagen mimetic peptides

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Abstract

Advanced lipid peroxidation end-products (ALEs) accumulate with ageing and oxidative stress-related diseases. Despite their potential therapeutic value, there are no suitably protected ALE building blocks reported in the literature to enable their site-specific incorporation into synthetic peptides. The synthesis of an Fmoc-protected ALE building block, Nāˆˆ-(3-methylpyridinium)lysine (MP-lysine) and its incorporation into collagen model peptides is reported.

Graphical abstract: Synthesis and incorporation of an advanced lipid peroxidation end-product building block into collagen mimetic peptides

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Article information


Submitted
29 Jun 2017
Accepted
06 Jul 2017
First published
06 Jul 2017

Chem. Commun., 2017,53, 8459-8462
Article type
Communication

Synthesis and incorporation of an advanced lipid peroxidation end-product building block into collagen mimetic peptides

I. Kavianinia, S. Yang, H. Kaur, P. W. R. Harris, R. C. J. Dobson, A. J. Fairbanks and M. A. Brimble, Chem. Commun., 2017, 53, 8459
DOI: 10.1039/C7CC05025A

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