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Issue 65, 2017

Nickel-catalyzed C–H activation of purine bases with alkyl halides

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Abstract

C–H alkylations of purine nucleosides were achieved by means of user-friendly nickel catalysis with ample substrate scope and high levels of chemo, site and regio control, which among others enabled the direct fluorescent labeling of purines in terms of late stage diversification.

Graphical abstract: Nickel-catalyzed C–H activation of purine bases with alkyl halides

Supplementary files

Article information


Submitted
28 Jun 2017
Accepted
19 Jul 2017
First published
19 Jul 2017

Chem. Commun., 2017,53, 9113-9116
Article type
Communication

Nickel-catalyzed C–H activation of purine bases with alkyl halides

Z. Ruan, D. Ghorai, G. Zanoni and L. Ackermann, Chem. Commun., 2017, 53, 9113 DOI: 10.1039/C7CC05011A

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