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Issue 53, 2017
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Incorporation of native antibodies and Fc-fusion proteins on DNA nanostructures via a modular conjugation strategy

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Abstract

A photocrosslinkable protein G variant was used as an adapter protein to covalently and site-specifically conjugate an antibody and an Fc-fusion protein to an oligonucleotide. This modular approach enables straightforward decoration of DNA nanostructures with complex native proteins while retaining their innate binding affinity, allowing precise control over the nanoscale spatial organization of such proteins for in vitro and in vivo biomedical applications.

Graphical abstract: Incorporation of native antibodies and Fc-fusion proteins on DNA nanostructures via a modular conjugation strategy

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Supplementary files

Article information


Submitted
30 May 2017
Accepted
09 Jun 2017
First published
09 Jun 2017

This article is Open Access

Chem. Commun., 2017,53, 7393-7396
Article type
Communication

Incorporation of native antibodies and Fc-fusion proteins on DNA nanostructures via a modular conjugation strategy

B. J. H. M. Rosier, G. A. O. Cremers, W. Engelen, M. Merkx, L. Brunsveld and T. F. A. de Greef, Chem. Commun., 2017, 53, 7393
DOI: 10.1039/C7CC04178K

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