Issue 59, 2017

Allosteric control of nanomechanical DNA origami pinching devices for enhanced target binding

Abstract

Significant enhancement of single-molecular binding to a miRNA target and bidentate and asymmetric conjugation of two distinct thiolated DNA strands to single gold nanoparticles (AuNPs) were visibly demonstrated, by introducing two groups of ligands into our nanomechanical DNA origami devices (DNA pliers) to construct allosterically controllable systems.

Graphical abstract: Allosteric control of nanomechanical DNA origami pinching devices for enhanced target binding

Supplementary files

Article information

Article type
Communication
Submitted
23 May 2017
Accepted
26 Jun 2017
First published
27 Jun 2017

Chem. Commun., 2017,53, 8276-8279

Allosteric control of nanomechanical DNA origami pinching devices for enhanced target binding

A. Kuzuya, Y. Sakai, T. Yamazaki, Y. Xu, Y. Yamanaka, Y. Ohya and M. Komiyama, Chem. Commun., 2017, 53, 8276 DOI: 10.1039/C7CC03991C

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