Issue 57, 2017

Copper-mediated C–H cyanation of (hetero)arenes with ethyl (ethoxymethylene)cyanoacetate as a cyanating agent

Abstract

A copper-mediated direct C–H cyanation of (hetero)arenes with ethyl (ethoxymethylene)cyanoacetate as a safe cyanating agent has been successfully developed by using molecular oxygen as the oxidant. The reaction tolerates a variety of functional groups and provides a facile and efficient method for the synthesis of a wide range of (hetero)aryl nitriles.

Graphical abstract: Copper-mediated C–H cyanation of (hetero)arenes with ethyl (ethoxymethylene)cyanoacetate as a cyanating agent

Supplementary files

Article information

Article type
Communication
Submitted
02 May 2017
Accepted
06 Jun 2017
First published
06 Jun 2017

Chem. Commun., 2017,53, 7994-7997

Copper-mediated C–H cyanation of (hetero)arenes with ethyl (ethoxymethylene)cyanoacetate as a cyanating agent

C. Qi, X. Hu and H. Jiang, Chem. Commun., 2017, 53, 7994 DOI: 10.1039/C7CC03384B

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