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Issue 73, 2017
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Construction of dye-stapled Quenchbodies by photochemical crosslinking to antibody nucleotide-binding sites

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Abstract

We successfully converted an antibody single-chain variable fragment and a full-sized antibody to Quenchbodies, which are a type of powerful fluorescent immunosensor, through ultraviolet-based photochemical crosslinking of an indole-3-butyric acid-conjugated fluorescent dye to the nucleotide-binding sites near the antigen-binding sites.

Graphical abstract: Construction of dye-stapled Quenchbodies by photochemical crosslinking to antibody nucleotide-binding sites

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Article information


Submitted
20 Apr 2017
Accepted
23 Aug 2017
First published
23 Aug 2017

Chem. Commun., 2017,53, 10200-10203
Article type
Communication

Construction of dye-stapled Quenchbodies by photochemical crosslinking to antibody nucleotide-binding sites

H. Jeong, K. Matsumoto, S. Itayama, K. Kodama, R. Abe, J. Dong, M. Shindo and H. Ueda, Chem. Commun., 2017, 53, 10200
DOI: 10.1039/C7CC03043F

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