Issue 59, 2017
From the journal:

Chemical Communications

An alkylating immobilization linker for immunochemical epigenetic assessment†

Takaaki Kurinomaru,a   Naoshi Kojimaa  and  Ryoji Kurita ORCID logo *a  

* Corresponding authors

a Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST) and DAILAB, Tsukuba Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki, Japan
E-mail: r.kurita@aist.go.jp

Abstract

A bifunctional linker molecule containing nitrogen mustard and a cyclic disulfide group has been developed for the covalent immobilization of intact DNA, which allows quantitative analysis of epigenomic modification in immobilized DNA using SPR-based immune sensing.

Graphical abstract: An alkylating immobilization linker for immunochemical epigenetic assessment

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Article information

DOI
https://doi.org/10.1039/C7CC02883K
Article type
Communication
Submitted
14 Apr 2017
Accepted
29 Jun 2017
First published
30 Jun 2017

Chem. Commun., 2017,53, 8308-8311

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An alkylating immobilization linker for immunochemical epigenetic assessment

T. Kurinomaru, N. Kojima and R. Kurita, Chem. Commun., 2017, 53, 8308 DOI: 10.1039/C7CC02883K

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