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Issue 55, 2017
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Dual-channel signals for intracellular mRNA detection via a PRET nanosensor

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Abstract

An intracellular nanosensor was designed and developed to accurately sense mRNA in living cells without false positive results. This nanosensor consists of gold nanoparticles assembled with recognition sequences and dye-labelled nanoflares. By analyzing both the wavelength shifts and intensity recovery of the scattering spectra, this dual-channel nanosensor could efficiently distinguish and avoid the interference induced by other common substances. This novel dual-channel nanosensor would precisely recognize the target mRNA, and it is promising for further cancer diagnoses.

Graphical abstract: Dual-channel signals for intracellular mRNA detection via a PRET nanosensor

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Publication details

The article was received on 13 Apr 2017, accepted on 16 Jun 2017 and first published on 16 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC02864D
Chem. Commun., 2017,53, 7768-7771

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    Dual-channel signals for intracellular mRNA detection via a PRET nanosensor

    T. Xie, M. Li and Y. Long, Chem. Commun., 2017, 53, 7768
    DOI: 10.1039/C7CC02864D

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