Issue 57, 2017

Improving bioassay sensitivity through immobilization of bio-probes onto reactive micelles

Abstract

An antigen probe (HIV-1 p24) immobilized onto N-succinimidyl ester based micelles was used as a solid phase coating in ELISA test, and induced a significant improvement in antibody detection sensitivity as compared to the standard free antigen coating. The relevance of this straightforward approach to improve the bioassay sensitivity was confirmed by using biotin as a generic probe.

Graphical abstract: Improving bioassay sensitivity through immobilization of bio-probes onto reactive micelles

Supplementary files

Article information

Article type
Communication
Submitted
17 Mar 2017
Accepted
19 Jun 2017
First published
22 Jun 2017

Chem. Commun., 2017,53, 8062-8065

Improving bioassay sensitivity through immobilization of bio-probes onto reactive micelles

G. Jiménez-Sánchez, C. Terrat, B. Verrier, D. Gigmes and T. Trimaille, Chem. Commun., 2017, 53, 8062 DOI: 10.1039/C7CC02057K

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