Issue 41, 2017
From the journal:

Chemical Communications

Photo-cleavable analog of BAPTA for the fast and efficient release of Ca2+†

Mariia V. Sutton,a   Matthew McKinley,a   Revathy Kulasekharana  and  Vladimir V. Popik*a  

* Corresponding authors

a Department of Chemistry, University of Georgia, Athens, GA 30677, USA
E-mail: vpopik@uga.edu

Abstract

A new photocleavable analog of BAPTA chelating ligand has a high affinity towards Ca2+ ions (K = 2.5 × 106 M−1). The use of photolabile 3-(hydroxymethyl)-2-naphthol core in the design of photo-BAPTA allows for the efficient (Φ = 0. 63) and very fast (τ < 12 μs) release of Ca2+ ions upon 300 or 350 nm irradiation.

Graphical abstract: Photo-cleavable analog of BAPTA for the fast and efficient release of Ca2+

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Article information

DOI
https://doi.org/10.1039/C7CC02056B
Article type
Communication
Submitted
17 Mar 2017
Accepted
03 Apr 2017
First published
05 Apr 2017

Chem. Commun., 2017,53, 5598-5601

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Photo-cleavable analog of BAPTA for the fast and efficient release of Ca2+

M. V. Sutton, M. McKinley, R. Kulasekharan and V. V. Popik, Chem. Commun., 2017, 53, 5598 DOI: 10.1039/C7CC02056B

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