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Issue 45, 2017
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Lanthanoplatins: emissive Eu(iii) and Tb(iii) complexes staining nucleoli targeted through Pt–DNA crosslinking

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Abstract

Two highly luminescent water-soluble heterometallic LnPt2 complexes, [{cis-PtCl(NH3)2}2Ln(L)(H2O)](NO3)2 (Ln = Eu (1), Tb (2)), have been designed for their selective nucleoli staining through formation of Pt–DNA crosslinks. The complexes showed significant cellular uptake and distinctive nucleoli localization through intrinsic emission from EuIII or TbIII observed through confocal fluorescence microscopy.

Graphical abstract: Lanthanoplatins: emissive Eu(iii) and Tb(iii) complexes staining nucleoli targeted through Pt–DNA crosslinking

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Article information


Submitted
17 Mar 2017
Accepted
12 May 2017
First published
12 May 2017

Chem. Commun., 2017,53, 6144-6147
Article type
Communication

Lanthanoplatins: emissive Eu(III) and Tb(III) complexes staining nucleoli targeted through Pt–DNA crosslinking

K. Singh, S. Singh, P. Srivastava, S. Sivakumar and A. K. Patra, Chem. Commun., 2017, 53, 6144
DOI: 10.1039/C7CC02047C

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