A phenazine-barbituric acid based colorimetric and ratiometric near-infrared fluorescent probe for sensitively differentiating biothiols and its application in TiO2 sensor devices

Xiao Zhang; Yongchao Yan; Yandi Hang; Jian Wang; Jianli Hua; He Tian

doi:10.1039/C7CC01925D

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A phenazine-barbituric acid based colorimetric and ratiometric near-infrared fluorescent probe for sensitively differentiating biothiols and its application in TiO₂ sensor devices†

Xiao Zhang,^a Yongchao Yan,^a Yandi Hang,^a Jian Wang,^a Jianli Hua

*^a and He Tian^a

Author affiliations

* Corresponding authors

^a Key Laboratory for Advanced Materials, Institute of Fine Chemicals, College of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, P. R. China
E-mail: jlhua@ecust.edu.cn

Abstract

A new colorimetric and ratiometric near-infrared fluorescent probe based on phenazine-barbituric acid was developed to ultrasensitively detect biothiols. The favorable ratiometric changes helped the imaging and differentiation of Cys in living cells. Besides, the probe was successfully employed to construct TiO₂ sensor devices, which could quantify Hcy concentration in serum.

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Article information

DOI: https://doi.org/10.1039/C7CC01925D
Article type: Communication
Submitted: 14 Mar 2017
Accepted: 03 May 2017
First published: 03 May 2017

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Chem. Commun., 2017,53, 5760-5763

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A phenazine-barbituric acid based colorimetric and ratiometric near-infrared fluorescent probe for sensitively differentiating biothiols and its application in TiO₂ sensor devices

X. Zhang, Y. Yan, Y. Hang, J. Wang, J. Hua and H. Tian, Chem. Commun., 2017, 53, 5760 DOI: 10.1039/C7CC01925D

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Chemical Communications