Lighting-up breast cancer cells by a near-infrared fluorescent probe based on KIAA1363 enzyme-targeting

Jiangli Fan; Shigang Guo; Suzhen Wang; Yao Kang; Qichao Yao; Jia Wang; Xue Gao; Hongjiang Wang; Jianjun Du; Xiaojun Peng

doi:10.1039/C7CC01798G

Lighting-up breast cancer cells by a near-infrared fluorescent probe based on KIAA1363 enzyme-targeting†

Jiangli Fan,*^a Shigang Guo,^a Suzhen Wang,^a Yao Kang,^a Qichao Yao,^a Jia Wang,*^b Xue Gao,^c Hongjiang Wang,^b Jianjun Du^a and Xiaojun Peng

^a

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* Corresponding authors

^a State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, P. R. China
E-mail: fanjl@dlut.edu.cn

^b Department of Breast Surgery, The Second Hospital of Dalian Medical University, Dalian, P. R. China
E-mail: wangjia0829jp@yahoo.co.jp

^c Department of Pathology, First Affiliated Hospital of Dalian Medical University, Dalian, P. R. China

Abstract

The first NIR KIAA1363-targeting probe, NB-AX, specifically and instantly featured an “off–on” switch upon gradual addition of KIAA1363 over all kinds of other biomolecules, and its detection limit was initially calculated to be 0.58 μg mL⁻¹ (3δ/k). The probe was also able to be used in ultrafast distinguishing of breast cancer cells from normal cells in fluorescence imaging and applied in tissue imaging and tumor imaging in vivo.

Chemical Communications

Lighting-up breast cancer cells by a near-infrared fluorescent probe based on KIAA1363 enzyme-targeting†

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Lighting-up breast cancer cells by a near-infrared fluorescent probe based on KIAA1363 enzyme-targeting

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