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Issue 40, 2017
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Intratumoral H2O2-triggered release of CO from a metal carbonyl-based nanomedicine for efficient CO therapy

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Abstract

A new H2O2-responsive nanomedicine for CO therapy is constructed by effectively encapsulating the hydrophobic manganese carbonyl prodrug into an advanced hollow mesoporous silica nanoparticle carrier to realize the intratumoral H2O2-triggered release of CO and selective killing of tumour cells rather than normal cells, exhibiting high in vitro and in vivo efficacies of CO therapy.

Graphical abstract: Intratumoral H2O2-triggered release of CO from a metal carbonyl-based nanomedicine for efficient CO therapy

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Article information


Submitted
02 Mar 2017
Accepted
18 Apr 2017
First published
26 Apr 2017

Chem. Commun., 2017,53, 5557-5560
Article type
Communication

Intratumoral H2O2-triggered release of CO from a metal carbonyl-based nanomedicine for efficient CO therapy

Z. Jin, Y. Wen, L. Xiong, T. Yang, P. Zhao, L. Tan, T. Wang, Z. Qian, B. Su and Q. He, Chem. Commun., 2017, 53, 5557
DOI: 10.1039/C7CC01576C

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