Issue 26, 2017
From the journal:

Chemical Communications

Illuminating cytochrome P450 binding: Ru(ii)-caged inhibitors of CYP17A1†

Ao Li,a   Rahul Yadav,b   Jessica K. White, ORCID logo c   Mackenzie K. Herroon,d   Brian P. Callahan,e   Izabela Podgorski,*df   Claudia Turro,*c   Emily E. Scott*b  and  Jeremy J. Kodanko ORCID logo *af  

* Corresponding authors

a Department of Chemistry, Wayne State University, Detroit, MI 48202, USA
E-mail: jkodanko@chem.wayne.edu
Tel: +1 313 577 9043

b Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA

c Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA

d Department of Pharmacology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA

e Department of Chemistry, Binghamton University, Binghamton, New York 13902, USA

f Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA

Abstract

New Ru(II)-caged abiraterone complexes were synthesized that exhibit strong absorption in the visible region and release the steroidal CYP17A1 inhibitor abiraterone upon exposure to low energy visible light in buffer and prostate cancer cells. Photoinduced release results in abiraterone binding to its CYP17A1 target in an inhibitory mode.

Graphical abstract: Illuminating cytochrome P450 binding: Ru(ii)-caged inhibitors of CYP17A1

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Article information

DOI
https://doi.org/10.1039/C7CC01459G
Article type
Communication
Submitted
23 Feb 2017
Accepted
07 Mar 2017
First published
07 Mar 2017

Chem. Commun., 2017,53, 3673-3676

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Illuminating cytochrome P450 binding: Ru(II)-caged inhibitors of CYP17A1

A. Li, R. Yadav, J. K. White, M. K. Herroon, B. P. Callahan, I. Podgorski, C. Turro, E. E. Scott and J. J. Kodanko, Chem. Commun., 2017, 53, 3673 DOI: 10.1039/C7CC01459G

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