Issue 23, 2017
From the journal:

Chemical Communications

A new and potentially prebiotic α-cytidine derivative†

Maria Tsanakopoulou, ORCID logo a   Jianfeng Xu,a   Andrew D. Bondb  and  John D. Sutherland*a  

* Corresponding authors

a MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, UK
E-mail: johns@mrc-lmb.cam.ac.uk

b Department of Chemistry, University of Cambridge, Lensfield Road, UK

Abstract

A new α-cytidine derivative was synthesised from the prebiotic reaction of ribose aminooxazoline and dicyanoacetylene. The tetracyclic structure of the product was confirmed by X-ray diffraction and then an alternative 6-step synthetic pathway to the product was found which was suitable for large-scale synthesis.

Graphical abstract: A new and potentially prebiotic α-cytidine derivative

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Article information

DOI
https://doi.org/10.1039/C7CC00693D
Article type
Communication
Submitted
24 Jan 2017
Accepted
15 Feb 2017
First published
23 Feb 2017
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 3327-3329

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A new and potentially prebiotic α-cytidine derivative

M. Tsanakopoulou, J. Xu, A. D. Bond and J. D. Sutherland, Chem. Commun., 2017, 53, 3327 DOI: 10.1039/C7CC00693D

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