A mitochondria-targeted fluorescent probe for imaging endogenous malondialdehyde in HeLa cells and onion tissues

Longwei He; Xueling Yang; Kaixin Xu; Weiying Lin

doi:10.1039/C7CC00512A

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A mitochondria-targeted fluorescent probe for imaging endogenous malondialdehyde in HeLa cells and onion tissues†

Longwei He,

^a Xueling Yang,^a Kaixin Xu^a and Weiying Lin

*^a

Author affiliations

* Corresponding authors

^a Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Materials Science and Engineering, University of Jinan, Shandong 250022, P. R. China
E-mail: weiyinglin2013@163.com

Abstract

The mitochondria-targeted turn-on fluorescent probe (Mito-FMP) based on a benzoxadiazole platform was developed for detection of malondialdehyde (MDA). Mito-FMP performed with large enhancement of the optical signal (774-fold) in response to MDA in an aqueous system and has the capability of monitoring endogenous MDA in HeLa cells and onion tissues.

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Article information

DOI: https://doi.org/10.1039/C7CC00512A
Article type: Communication
Submitted: 19 Jan 2017
Accepted: 18 Mar 2017
First published: 20 Mar 2017

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Chem. Commun., 2017,53, 4080-4083

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A mitochondria-targeted fluorescent probe for imaging endogenous malondialdehyde in HeLa cells and onion tissues

L. He, X. Yang, K. Xu and W. Lin, Chem. Commun., 2017, 53, 4080 DOI: 10.1039/C7CC00512A

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Chemical Communications

A mitochondria-targeted fluorescent probe for imaging endogenous malondialdehyde in HeLa cells and onion tissues†

Abstract

Supplementary files

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A mitochondria-targeted fluorescent probe for imaging endogenous malondialdehyde in HeLa cells and onion tissues

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