Issue 9, 2017
From the journal:

Chemical Communications

Harnessing ester bond chemistry for protein ligation†

P. G. Young,‡ab   Y. Yosaatmadja,‡a   P. W. R. Harris,ab   I. K. H. Leung, ORCID logo c   E. N. Bakerab  and  C. J. Squire ORCID logo *ab  

* Corresponding authors

a School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
E-mail: c.squire@auckland.ac.nz

b Maurice Wilkins Centre for Molecular Biodiscovery, c/o The University of Auckland, Private Bag 92019, Auckland, New Zealand

c School of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand

Abstract

The hydrolysis potential of ester bonds in covalently cross-linking proteins is captured in our novel protein ligation technology. This new type of “molecular superglue” based on the spontaneously-formed Thr–Gln ester bonds found in cell-surface adhesins, affords a unique mechanism to both rationally assemble and disassemble complex protein nanomaterials.

Graphical abstract: Harnessing ester bond chemistry for protein ligation

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Article information

DOI
https://doi.org/10.1039/C6CC09899A
Article type
Communication
Submitted
13 Dec 2016
Accepted
27 Dec 2016
First published
03 Jan 2017

Chem. Commun., 2017,53, 1502-1505

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Harnessing ester bond chemistry for protein ligation

P. G. Young, Y. Yosaatmadja, P. W. R. Harris, I. K. H. Leung, E. N. Baker and C. J. Squire, Chem. Commun., 2017, 53, 1502 DOI: 10.1039/C6CC09899A

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