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Issue 13, 2017
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The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A

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Abstract

JIB-04, a specific inhibitor of the O2-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O2 in KDM4A/JMJD2A through a continuous O2-consumption assay, X-ray crystal structure data, and molecular docking.

Graphical abstract: The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A

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Article information


Submitted
12 Dec 2016
Accepted
23 Jan 2017
First published
23 Jan 2017

Chem. Commun., 2017,53, 2174-2177
Article type
Communication

The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A

B. Cascella, S. G. Lee, S. Singh, J. M. Jez and L. M. Mirica, Chem. Commun., 2017, 53, 2174
DOI: 10.1039/C6CC09882G

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