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Issue 27, 2017
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Synthesis and evaluation of a tag-free photoactive phospho-ceramide analogue-1 (PCERA-1) probe to study immunomodulation in macrophages

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Abstract

Phospho-ceramide analogue-1 (PCERA-1), a synthetic analogue of ceramide-1-phosphate (C1P), has been previously shown to act as a potent modulator of macrophage activity and inflammation. We have developed an efficient synthesis of PCERA-1 from readily available starting materials, and designed and prepared derivatives of this analogue, including a photoaffinity probe to tag and identify putative proteins that bind PCERA-1.

Graphical abstract: Synthesis and evaluation of a tag-free photoactive phospho-ceramide analogue-1 (PCERA-1) probe to study immunomodulation in macrophages

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Supplementary files

Article information


Submitted
11 Dec 2016
Accepted
08 Mar 2017
First published
10 Mar 2017

Chem. Commun., 2017,53, 3842-3845
Article type
Communication

Synthesis and evaluation of a tag-free photoactive phospho-ceramide analogue-1 (PCERA-1) probe to study immunomodulation in macrophages

R. Dandela, R. Mashiach, R. Adepu, R. Gregor, M. Athamna, E. Zecharia, O. Ernst, T. Zor and M. M. Meijler, Chem. Commun., 2017, 53, 3842
DOI: 10.1039/C6CC09849E

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