Temperature responsive lipid liquid crystal layers with embedded nanogels

A. P. Dabkowska; C. Hirst; M. Valldeperas; L. A. Clifton; C. Montis; S. Nöjd; L. Gentile; M. Wang; G. K. Pálsson; S. Lages; D. Berti; J. Barauskas; T. Nylander

doi:10.1039/C6CC09426K

Temperature responsive lipid liquid crystal layers with embedded nanogels†

A. P. Dabkowska,

*^a C. Hirst,^a M. Valldeperas,

^a L. A. Clifton,^b C. Montis,

^cd S. Nöjd,^a L. Gentile,^a M. Wang,^a G. K. Pálsson,^ef S. Lages,^gh D. Berti,^cd J. Barauskas^ij and T. Nylander*^a

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* Corresponding authors

^a Division of Physical Chemistry, Lund University, P.O. Box 124, SE-22100 Lund, Sweden
E-mail: aleksandra.dabkowska@fkem1.lu.se, tommy.nylander@fkem1.lu.se

^b ISIS Pulsed Neutron and Muon Source, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Oxford Campus, Didcot, Oxfordshire, UK

^c Department of Chemistry, University of Florence, Italy

^d CSGI, Florence, Italy

^e Institut Laue Langevin, France

^f Department of Physics, Uppsala University, Box 530, SE-751 21 Uppsala, Sweden

^g Max IV Laboratory, Lund University, P.O. Box 118, SE-22100 Lund, Sweden

^h Crystallography and Structure Physics, Physics Department, Friedrich-Alexander-Universität, Erlangen-Nürnberg, Erlangen, Germany

ⁱ Biomedical Science, Faculty of Health and Society, Malmö University, SE-20506, Malmö, Sweden

^j Camurus AB, Ideon Science Park, Gamma Building, Sölvegatan 41, SE-22379 Lund, Sweden

Abstract

Polymer nanogels are embedded within layers consisting of a nonlamellar liquid crystalline lipid phase to act as thermoresponsive controllers of layer compactness and hydration. As the nanogels change from the swollen to the collapsed state via a temperature trigger, they enable on-demand release of water from the mixed polymer–lipid layer while the lipid matrix remains intact. Combining stimuli-responsive polymers with responsive lipid-based mesophase systems opens up new routes in biomedical applications such as functional biomaterials, bioanalysis and drug delivery.

Chemical Communications

Temperature responsive lipid liquid crystal layers with embedded nanogels†

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Temperature responsive lipid liquid crystal layers with embedded nanogels

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